Bottom‐Up Preparation of Uniform Ultrathin Rhenium Disulfide Nanosheets for Image‐Guided Photothermal Radiotherapy. (23rd May 2017)

• Record Type: Journal Article
• Authors: Shen, Sida; Chao, Yu; Dong, Ziliang; Wang, Guanglin; Yi, Xuan; Song, Guosheng; Yang, Kai; Liu, Zhuang; Cheng, Liang
• Is Part Of: Advanced functional materials. Volume 27:Number 28(2017)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2017-05-23
• Subjects: cancer therapy -- chelator‐free 99mTc labeling -- multimodal imaging -- radiotherapy -- ReS2 nanosheets -- synergistic effects; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adfm.201700250
• Languages: English
• ISSNs: 1616-301X

Abstract

Abstract : Facile preparation of multifunctional theranostic nanoplatforms with well‐controlled morphology and sizes remains an attractive in the area of nanomedicine. Here, a new kind of 2D transition metal dichalcogenide, rhenium disulfide (ReS2 ) nanosheets, with uniform sizes, strong near‐infrared (NIR) light, and strong X‐ray attenuation, is successfully synthesized. After surface modification with poly(ethylene glycol) (PEG), the synthesized ReS2 ‐PEG nanosheets are stable in various physiological solutions. In addition to their contrasts in photoacoustic imaging and X‐ray computed tomography imaging because of their strong NIR light and X‐ray absorptions, respectively, such ReS2 ‐PEG nanosheets can also be tracked under nuclear imaging after chelator‐free labeling with radioisotope ions, 99m Tc 4+ . Efficient tumor accumulation of ReS2 ‐PEG nanosheets is then observed after intravenous injection into tumor‐bearing mice under triple‐modal imaging. The combined in vivo photothermal radiotherapy is further conducted, achieving a remarkable synergistic tumor destruction effect. Finally, no obvious toxicity of ReS2 ‐PEG nanosheets is observed from the treated mice within 30 d. This work suggests that such ultrathin ReS2 nanosheets with well‐controlled morphology and uniform sizes may be a promising type of multifunctional theranostic agent for remotely triggered cancer combination therapy. Abstract : A one‐step bottom‐up method is developed to synthesize a new kind of transition metal dichalcogenide (TMDC), rhenium disulfide (ReS2 ), with well‐defined 2D nanosheet morphology and uniform sizes, for multimodal imaging‐guided cancer combination therapy.