A comprehensive evaluation of the toxicology of the "Deli" cast sheet process used in experimental cigarettes. (12th December 2013)

• Record Type: Journal Article
• Authors: Coggins, Christopher R. E.; Merski, Jerome A.; Oldham, Michael J.
• Is Part Of: Inhalation toxicology. Volume 25(2013)Supplement 2
• Page Start: 64
• Page End: 68
• Publication Date: 2013-12-12
• Subjects: Cigarette components -- reconstituted tobacco -- smoke chemistry -- toxicological testing; Pulmonary toxicology -- Animal models -- Periodicals; Pulmonary toxicology -- Periodicals; Air -- Pollution -- Health aspects -- Periodicals; 616.200471
• DOI: 10.3109/08958378.2013.854435
• Languages: English
• ISSNs: 0895-8378

Abstract

Abstract: Context : Manufacture of cigarettes results in tobacco by-products, some of which can be processed and added back to cigarettes. Such additions (known as reconstituted tobacco or reconstituted leaf) have been shown to reduce tar yields. A new process (termed "Deli" cast sheet) is a potential refinement of the reconstitution process. Objective : Compare toxicity of smoke from experimental cigarettes made with reconstituted leaf with that from cigarettes made with Deli cast sheet. Materials and methods : Analytical chemistry, Salmonella mutagenicity and cytotoxicity assays were used to evaluate the composition biological activity of mainstream smoke from experimental cigarettes made with Deli cast sheet or with reconstituted leaf. The effect of different amounts of guar and propylene glycol in Deli cast sheet was also evaluated. Results : Small increases in the amount of nitrogen oxides were found as a result of inclusion of the Deli cast sheet when compared with reconstituted leaf; no differences in cytotoxicity or mutagenicity were found. Conclusion : The Deli process neither significantly modified chemical composition of smoke nor affected its biological activity, as measured by the mutagenicity and cytotoxicity assays used here.