Cucurbit[7]uril: an emerging candidate for pharmaceutical excipients. Issue 1 (June 2017)

• Record Type: Journal Article
• Authors: Kuok, Kit Ieng; Li, Shengke; Wyman, Ian W.; Wang, Ruibing
• Other Names: Xiao Jianbo guestEditor.
• Is Part Of: Annals of the New York Academy of Sciences. Volume 1398:Issue 1(2017)
• Page Start: 108
• Page End: 119
• Publication Date: 2017-06
• Subjects: cucurbit[7]uril -- host–guest complexes -- supramolecular chemistry -- excipients -- formulation; Medical sciences -- Periodicals; Medicine -- Periodicals; Science -- Periodicals; 610
• DOI: 10.1111/nyas.13376
• Languages: English
• ISSNs: 0077-8923

Abstract

Abstract : Cucurbit[7]uril (CB[7]), belonging to the cucurbit[ n ]uril family (CB[ n ], n = 5–8, 10, or 13–15), may form host–guest complexes with a variety of small molecules of biomedical interest. The physical and chemical properties of the complexed drugs are often improved as a result of this complexation, suggesting the potential application of CB[7] as a pharmaceutical excipient. This review has summarized the most recent research progress reported between 2011 and early 2017 regarding the biocompatibility of CB[7] and the influence of CB[7] on the stability, solubility, biouptake, and biological activities (including therapeutic efficacies and toxicities) of guest drug molecules. Through this systemic summary and analysis, we intend to stimulate further research efforts in this area and promote the use of CB[7] as an emerging pharmaceutical excipient to improve various properties of drug molecules (or active pharmaceutical ingredients).