Primary Cell Phenotypic Screening Illuminates ADRs and AOPs. Issue 7 (20th July 2017)

• Record Type: Journal Article
• Authors: Bone, Audrey J.; Houck, Keith A.
• Is Part Of: Cell chemical biology. Volume 24:Issue 7(2017)
• Page Start: 781
• Page End: 782
• Publication Date: 2017-07-20
• Subjects: Biochemistry -- Periodicals; 572.05
• DOI: 10.1016/j.chembiol.2017.07.001
• Languages: English
• ISSNs: 2451-9456

Abstract

Abstract : Preclinical, in vitro screening for adverse drug reactions continues to present challenges in the field of drug development. In this issue of Cell Chemical Biology, Shah et al. (2017) employ a phenotypic screening strategy using a panel of human primary cells to define a signature response and an adverse outcome pathway for delayed type IV skin hypersensitivity. Abstract : Preclinical, in vitro screening for adverse drug reactions continues to present challenges in the field of drug development. In this issue of Cell Chemical Biology, Shah et al. (2017) employ a phenotypic screening strategy using a panel of human primary cells to define a signature response and an adverse outcome pathway for delayed type IV skin hypersensitivity.