Zoledronic acid and alendronate sodium and the implications in orthodontic movement. (27th June 2017)

• Record Type: Journal Article
• Authors: Franzoni, J. S.; Soares, F. M. P.; Zaniboni, E.; Vedovello Filho, M.; Santamaria, M. P.; dos Santos, G. M. T.; Esquisatto, M. A. M.; Felonato, M.; Mendonca, F. A. S.; Franzini, C. M.; Santamaria, M.
• Is Part Of: Orthodontics and craniofacial research. Volume 20:Number 3(2017)
• Page Start: 164
• Page End: 169
• Publication Date: 2017-06-27
• Subjects: adverse effects -- alendronate sodium -- bisphosphonates -- orthodontic tooth movement -- zoledronic acid; Skull -- Growth -- Periodicals; Facial bones -- Growth -- Periodicals; Orthodontics -- Periodicals; Orthodontics, Corrective -- Periodicals; Orthodontic appliances -- Periodicals; 617.51
• DOI: 10.1111/ocr.12192
• Languages: English
• ISSNs: 1601-6335

Abstract

Structured Abstract: Objective: To evaluate orthodontic tooth movement (OTM) in rats treated with two types of bisphosphonates (BPs), alendronate sodium (A) and zoledronic acid (Z). Design: In all, 15 male Wistar rats were randomly divided into three groups. Group OTM+A: orthodontic tooth movement and subcutaneous administration of alendronate sodium (2.5 mg/kg); Group OTM+Z: orthodontic tooth movement and subcutaneous administration of zoledronic acid (0.02 mg/kg), and Group OTM: orthodontic tooth movement and subcutaneous injection of saline. The BPs were administered once a day during 25 days before OTM started and during 10 days of OTM. The left upper first molar was moved with a stainless‐steel closed coil spring which delivered an initial force of 0.4N. OTM was measured with a digital caliper comparing the moved and the contralateral side. The histomorphometric analysis counted the number of osteoclasts, inflammatory cells, blood vessels and fibroblasts (n/10 4 m 2 ) in periodontal ligament (PDL) of the distobuccal root. Results: A reduction of 58.3% of OTM was found in Group OTM+A and 99.6% in Group OTM+Z, when compared with Group OTM. There was a significant decrease of osteoclasts and inflammatory cells in BP‐treated groups. Blood vessels and fibroblastic cells decreased mainly in Group OTM+Z. Conclusion: Alendronate sodium and zoledronic acid have similar effects on the periodontal tissue during orthodontic treatment in rats. Especially, zoledronic acid can affect orthodontic tooth movement.