Lichenoid Drug Eruption with Prominent Nail Changes Due to Leflunomide in a 12‐Year‐Old Child. Issue 4 (23rd May 2017)

• Record Type: Journal Article
• Authors: May, Caitlin; Fleckman, Philip; Brandling‐Bennett, Heather A.; Cole, Bonnie; Sidbury, Robert
• Is Part Of: Pediatric dermatology. Volume 34:Issue 4(2017:Jul./Aug.)
• Page Start: e225
• Page End: e226
• Publication Date: 2017-05-23
• Subjects: Pediatric dermatology -- Periodicals; Children -- Diseases -- Periodicals; 618.925
• DOI: 10.1111/pde.13168
• Languages: English
• ISSNs: 0736-8046

Abstract

Abstract: We present the case of a 12‐year‐old‐girl who developed lichenoid dermatitis approximately 1 year after starting leflunomide for juvenile idiopathic arthritis. The eruption resolved promptly with discontinuation of the suspected culprit agent, supportive of a lichenoid drug eruption, but she subsequently developed markedly dystrophic nails with lichen planus–like features. A biopsy of her cutaneous findings at the time of initial presentation demonstrated lichenoid dermatitis, and a nail matrix biopsy was deferred given clinical correlation. Prominent nail changes in lichenoid drug eruptions, particularly in children, are rare but should be considered in children with new‐onset nail dystrophy.