Cu(II) and Ni(II) Complexes of Anthracene‐Affixed Schiff Base: A Conflict between Covalent and Stacking Interactions with DNA Bases. Issue 20 (11th July 2017)

• Record Type: Journal Article
• Authors: Kathiresan, Sellamuthu; Annaraj, Jamespandi; Bhuvanesh, Nattamai S. P.
• Is Part Of: ChemistrySelect. Volume 2:Issue 20(2017)
• Page Start: 5475
• Page End: 5484
• Publication Date: 2017-07-11
• Subjects: Apoptosis -- BSA binding -- Cytotoxicity -- DNA interaction -- X-ray diffraction; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.201700693
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: Four new mononuclear complexes [Cu(L1)Cl2 ] (1 ), [Ni(L1)Cl2 ] (2 ), [Cu(L2)Cl2 ] (3 ) and [Ni(L2)Cl2 ] (4 ), where L1 (1‐(anthracen‐9‐yl)‐N‐(1H‐benzo[d]imidazole‐2‐yl)methanimine) and L2 (1‐(anthracen‐9‐yl)‐N‐(benzo[d]thiazol‐2yl)methanimine) have been synthesized and characterized by various spectral and electro analytical techniques. The molecular structure of the ligands L1 and L2 were determined by the single crystal XRD method. The absorption and emission spectral approaches revealed that these complexes may partially be stacking in between the DNA bases. In contrast, the possibility of their covalent interaction was evaluated through the cyclic voltammetric techniques. All these obtained results revealed that the complexes1‐4 could interact with HS‐DNA via covalent/partial intercalation modes and the quenching mechanism of BSA by all these complexes are through static mode. In addition, the in vitro cytotoxicity of the complexes on human gastric cancer cell lines have been observed by MTT and the fluorescence‐based morphological assessment obtained using Hoechst 33342 staining reveals that these complexes induces apoptosis against AGS cancer cells, among them best result was obtained for complex3 (8.9 μM). Abstract : Mononuclear complexes of Cu and Ni have been studied against DNA and BSA interaction studies with DNA showing a covalent/partial intercalation mode of interaction and BSA exhibiting a static mode. The cytotoxicity of the complexes towards AGS human gastric cancer cells were also determined.