Diastereoselective synthesis of highly functionalized polycyclic benzosultams via tandem cyclisations of cyclic N-sulfonylimines with in situ generated Huisgen 1, 4-dipoles. Issue 66 (28th June 2016)

• Record Type: Journal Article
• Authors: Zhao, Hong-Wu; Chen, Xiao-Qin; Pang, Hai-Liang; Tian, Ting; Li, Bo; Song, Xiu-Qing; Meng, Wei; Yang, Zhao; Zhao, Yu-Di; Liu, Yue-Yang
• Is Part Of: RSC advances. Volume 6:Issue 66(2016)
• Page Start: 61732
• Page End: 61739
• Publication Date: 2016-06-28
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c6ra12771a
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : The tandem cycloadditions of cyclic N -sulfonylimines with in situ generated Huisgen 1, 4-dipoles underwent readily, and delivered 1, 2, 3, 4-tetrahydropyrimidine-fused benzosultams in acceptable chemical yields with excellent diastereoselectivities. Abstract : Under mild reaction conditions, the tandem cycloadditions of cyclic N -sulfonylimines with in situ generated Huisgen 1, 4-dipoles from dialkyl acetylenedicarboxylates and pyridines underwent readily, and delivered highly functionalized polycyclic 1, 2, 3, 4-tetrahydropyrimidine-fused benzosultams in low to excellent chemical yields with excellent diastereoselectivities.