The role of functional imaging in the tumor patient. (December 2013)

• Record Type: Journal Article
• Authors: Wehner, Tim
• Is Part Of: Epilepsia. Volume 54(2013)Supplement 9
• Page Start: 44
• Page End: 49
• Publication Date: 2013-12
• Subjects: Tumoral epilepsy -- Positron emission tomography -- Ictal SPECT -- Functional MRI -- Navigated transcranial magnetic stimulation; Epilepsy -- Periodicals; 616.853
• DOI: 10.1111/epi.12443
• Languages: English
• ISSNs: 0013-9580

Abstract

Summary: Functional imaging studies complement structural magnetic resonance imaging (MRI) in the assessment of patients with brain tumor–associated focal epilepsy. 11 C‐Methionine (MET) and 18 F‐fluoro‐ethyl‐l ‐tyrosine (FET) are amino acid analogues that highlight metabolically active areas in positron emission tomography (PET). Ictal single photon emission computed tomography (SPECT) can provide information about perilesional areas of seizure onset and early propagation. Functional MRI (fMRI) and diffusion tensor imaging (DTI) allow noninvasive identification of potentially eloquent motor, sensory, and language cortical areas and pathways with an accuracy of 10–15 mm compared to electrocortical stimulation (ECS). Repetitive navigated transcranial magnetic stimulation (TMS) allows even more precise noninvasive delineation of primary motor cortex. Information from functional imaging studies helps in the planning of brain tumor biopsies, resections, and the planning of intracranial video–electroencephalography (EEG) studies.