Intramolecular oxidative palladium-catalyzed diamination reactions of alkenyl sulfamates: an efficient synthesis of [1, 2, 5]thiadiazolo-fused piperazinones. Issue 62 (15th June 2016)

• Record Type: Journal Article
• Authors: Chiacchio, Ugo; Broggini, Gianluigi; Romeo, Roberto; Gazzola, Silvia; Chiacchio, Maria A.; Giofrè, Salvatore V.; Gabriele, Bartolo; Mancuso, Raffaella; Floresta, Giuseppe; Zagni, Chiara
• Is Part Of: RSC advances. Volume 6:Issue 62(2016)
• Page Start: 57521
• Page End: 57529
• Publication Date: 2016-06-15
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c6ra13141g
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : A palladium-catalyzed diamination domino process of sulfamates arising from glycine allylamides is reported. Abstract : A palladium-catalyzed diamination domino process of sulfamates arising from glycine allylamides is reported. The reaction leads to the formation of [1, 2, 5]thiadiazolo-fused piperazinones. The essential feature of the synthetic route is the use of PdCl2 (MeCN)2 /CuBr2, as a catalytic system which promotes the second amination process, leading to the bicycle ring-fused compounds in good yields.