Nano-antacids enhance pH neutralization beyond their bulk counterparts: synthesis and characterization. Issue 59 (6th June 2016)

• Record Type: Journal Article
• Authors: Raliya, Ramesh; Som, Avik; Shetty, Nishit; Reed, Nathan; Achilefu, Samuel; Biswas, Pratim
• Is Part Of: RSC advances. Volume 6:Issue 59(2016)
• Page Start: 54331
• Page End: 54335
• Publication Date: 2016-06-06
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c6ra12856d
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Antacids are crucial in the treatment of gastro-esophageal reflux disease and peptic ulcers. Abstract : Antacids are crucial in the treatment of gastro-esophageal reflux disease and peptic ulcers. Antacids based on the calcite phase of bulk calcium carbonate have been the standard for over fifty years. More recent research has shown that nanomaterial forms of such bulk materials often have improved properties. However, the metastable vaterite form of calcium carbonate is particularly difficult to synthesize as a nanomaterial, and thus has not been extensively studied. Here, we describe the synthesis of these particles and investigate them for antacid applications. Experimental and computational approaches show that nanoscale vaterite particles maintain neutral gastric pH values three times longer than commercial antacids.