Measurement of cardiac output from dynamic pulmonary circulation time CT. Issue 6 (12th May 2014)

• Record Type: Journal Article
• Authors: Yee, Seonghwan; Scalzetti, Ernest M.
• Is Part Of: Medical physics. Volume 41:Issue 6(2014)Part 1
• Page Start: n/a
• Page End: n/a
• Publication Date: 2014-05-12
• Subjects: Single‐slice -- Contrast -- Heart and lung dynamics -- Cardiac dynamics -- Probability theory, stochastic processes, and statistics; blood vessels -- computerised tomography -- diagnostic radiography -- medical image processing -- time series; CT pulmonary angiography -- dynamic CT -- cardiac output -- single slice -- aortic arch; Computerised tomographs -- Biological material, e.g. blood, urine; Haemocytometers -- Digital computing or data processing equipment or methods, specially adapted for specific applications -- Image data processing or generation, in general; Cardiac haemodynamics -- Vascular system -- Single slice computed tomography -- Medical image contrast -- Time series analysis -- Heart -- Image analysis; Medical physics -- Periodicals; Medical physics; Geneeskunde; Natuurkunde; Toepassingen; Biophysics; Periodicals; Periodicals; Electronic journals; 610.153
• DOI: 10.1118/1.4875676
• Languages: English
• ISSNs: 0094-2405

Abstract

Abstract : Purpose: To introduce a method of estimating cardiac output from the dynamic pulmonary circulation time CT that is primarily used to determine the optimal time window of CT pulmonary angiography (CTPA). Methods: Dynamic pulmonary circulation time CT series, acquired for eight patients, were retrospectively analyzed. The dynamic CT series was acquired, prior to the main CTPA, in cine mode (1 frame/s) for a single slice at the level of the main pulmonary artery covering the cross sections of ascending aorta (AA) and descending aorta (DA) during the infusion of iodinated contrast. The time series of contrast changes obtained for DA, which is the downstream of AA, was assumed to be related to the time series for AA by the convolution with a delay function. The delay time constant in the delay function, representing the average time interval between the cross sections of AA and DA, was determined by least square error fitting between the convoluted AA time series and the DA time series. The cardiac output was then calculated by dividing the volume of the aortic arch between the cross sections of AA and DA (estimated from the single slice CT image) by the average time interval, and multiplying the result by a correction factor. Results: The mean cardiac output value for the six patients was 5.11 (l/min) (with a standard deviation of 1.57 l/min), which is in good agreement with the literature value; the data for the other two patients were too noisy for processing. Conclusions: The dynamic single‐slice pulmonary circulation time CT series also can be used to estimate cardiac output.