Antimicrobial activity of levofloxacin – M33 peptide conjugation or combination. Issue 2 (30th November 2015)

• Record Type: Journal Article
• Authors: Ceccherini, Federica; Falciani, Chiara; Onori, Martina; Scali, Silvia; Pollini, Simona; Rossolini, Gian Maria; Bracci, Luisa; Pini, Alessandro
• Is Part Of: MedChemComm. Volume 7:Issue 2(2016:Feb.)
• Page Start: 258
• Page End: 262
• Publication Date: 2015-11-30
• Subjects: Pharmaceutical chemistry -- Periodicals; 615.19
• DOI: 10.1039/c5md00392j
• Languages: English
• ISSNs: 2040-2503

Abstract

Abstract : M33 is a branched antimicrobial peptide against Gram-negative bacteria. We reported its conjugation with levofloxacin and its antibacterial activity. Abstract : M33 is a branched peptide currently under preclinical characterization for development as a new drug against Gram-negative bacteria. Here we report its antibacterial activity in conjugation or combination with levofloxacin (LVFX), a fluoroquinolone antibiotic. Antibacterial assays showed no significant differences in activity when used in conjugation, while the combination of M33 and LVFX showed improved activity against Gram-negative bacteria. Combination treatment therefore opposes antimicrobial-resistance, restoring the effect of LVFX.