LincRNA-ROR promotes invasion, metastasis and tumor growth in pancreatic cancer through activating ZEB1 pathway. Issue 2 (1st May 2016)

• Record Type: Journal Article
• Authors: Zhan, Han-xiang; Wang, Yao; Li, Ce; Xu, Jian-wei; Zhou, Bin; Zhu, Jian-kang; Han, Hai-feng; Wang, Lei; Wang, Yun-shan; Hu, San-yuan
• Is Part Of: Cancer letters. Volume 374:Issue 2(2016)
• Page Start: 261
• Page End: 271
• Publication Date: 2016-05-01
• Subjects: Pancreatic cancer -- LincRNA-ROR -- Epithelial-mesenchymal transition -- ZEB1 -- Metastasis; Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2016.02.018
• Languages: English
• ISSNs: 0304-3835

Abstract

Highlights: LincRNA-ROR is upregulated in pancreatic cancer (PC) tissues. LincRNA-ROR promotes PC cells proliferation and invasion in vitro, enhanced tumorigenic and metastatic capacities in vivo . LincRNA-ROR enhances ZEB1 expression in PC. LincRNA-ROR mediates EMT, migration, and metastasis in PC may partly by activation of ZEB1 through inhibition of p53. Abstract: Pancreatic cancer (PC) remains one of the most lethal malignant tumors; early distant metastasis commonly results in poor prognosis. Recent studies confirmed the pivotal role of the long non-coding RNAs (lncRNAs) in tumorigenesis and metastasis of malignant tumors, including PC. However, little is known about the role of LincRNA-ROR (linc-ROR) in PC. In the present study, we found that linc-ROR was upregulated in PC tissues. Overexpression of linc-ROR promoted cells proliferation, migration, invasion and metastasis both in vitro and in a mouse model. Contrarily, knockdown of linc-ROR attenuated proliferation, invasion and distant metastasis. Mechanistically, we confirmed that linc-ROR up-regulates ZEB1 and then induces epithelial-mesenchymal transition (EMT), which promotes the aggressive biological behaviors of PC. Together, these results indicate that linc-ROR acts as an important regulator of ZEB1, can promote invasion and metastasis in PC, and may represent a novel therapeutic target.