Tumor heterogeneity and circulating tumor cells. Issue 2 (1st May 2016)

• Record Type: Journal Article
• Authors: Zhang, Chufeng; Guan, Yan; Sun, Yulan; Ai, Dan; Guo, Qisen
• Is Part Of: Cancer letters. Volume 374:Issue 2(2016)
• Page Start: 216
• Page End: 223
• Publication Date: 2016-05-01
• Subjects: Circulating tumor cells -- Tumor heterogeneity -- Single cell sequencing -- Tumor evolution -- Gene mutation; Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2016.02.024
• Languages: English
• ISSNs: 0304-3835

Abstract

Highlights: CTCs reveal the spatial and temporal heterogeneity of tumors. High concordance was observed in molecular features between CTCs and tumors. CTCs do not fully represent the full mutation spectrum of tumors. Using CTCs to profile tumors is useful in clinical practice. Abstract: In patients with cancer, individualized treatment strategies are generally guided by an analysis of molecular biomarkers. However, genetic instability allows tumor cells to lose monoclonality and acquire genetic heterogeneity, an important characteristic of tumors, during disease progression. Researchers have found that there is tumor heterogeneity between the primary tumor and metastatic lesions, between different metastatic lesions, and even within a single tumor (either primary or metastatic). Tumor heterogeneity is associated with heterogeneous protein functions, which lowers diagnostic precision and consequently becomes an obstacle to determining the appropriate therapeutic strategies for individual cancer patients. With the development of novel testing technologies, an increasing number of studies have attempted to explore tumor heterogeneity by examining circulating tumor cells (CTCs), with the expectation that CTCs may comprehensively represent the full spectrum of mutations and/or protein expression alterations present in the cancer. In addition, this strategy represents a minimally invasive approach compared to traditional tissue biopsies that can be used to dynamically monitor tumor evolution. The present article reviews the potential efficacy of using CTCs to identify both spatial and temporal tumor heterogeneity. This review also highlights current issues in this field and provides an outlook toward future applications of CTCs.