Calyculin: Nature's way of making the sponge-derived cytotoxin. Issue 6 (29th February 2016)

• Record Type: Journal Article
• Authors: Wakimoto, Toshiyuki; Egami, Yoko; Abe, Ikuro
• Is Part Of: Natural product reports. Volume 33:Issue 6(2016:Jun.)
• Page Start: 751
• Page End: 760
• Publication Date: 2016-02-29
• Subjects: Natural products -- Periodicals; Produits naturels -- Périodiques; 547.7
• DOI: 10.1039/c5np00123d
• Languages: English
• ISSNs: 0265-0568

Abstract

Abstract : In this highlight, we focus on the recent studies addressing nature's design and biogenesis of calyculin A, a cytotoxic compound isolated from the Japanese marine sponge Discodermia calyx . Abstract : Covering: up to 2015. Calyculin A is a major cytotoxic compound isolated from the Japanese marine sponge Discodermia calyx . Its potent cytotoxicity is attributable to the specific inhibition of protein phosphatases 1 and 2A, as in the case of okadaic acid and the microcystins. Its chemical structure is well-designed not only for enzyme inhibition but also for higher membrane permeability in order to impart its potent cytotoxicity. The biosynthetic gene cluster of this densely functionalized polyketide and nonribosomal peptide hybrid molecule was recently identified from the sponge–microbe association. The producer organism and the dynamic bioconversion process were also revealed. In this highlight, we focus on the recent studies addressing nature's design and biogenesis of the sponge-derived cytotoxin, calyculin A.