A cyclosporine derivative is a substrate of the oligopeptide transporter PepT112. Issue 5 (29th March 2016)
- Record Type:
- Journal Article
- Title:
- A cyclosporine derivative is a substrate of the oligopeptide transporter PepT112. Issue 5 (29th March 2016)
- Main Title:
- A cyclosporine derivative is a substrate of the oligopeptide transporter PepT112
- Authors:
- Foley, David W.
Bermudez, Isabel
Bailey, Patrick D.
Meredith, David - Abstract:
- Abstract : Cyclosporine was attached to a thiodipeptide carrier, yielding conjugate7 ; this is a substrate for PepT1 with oral bioavailability potential. Abstract : The mammalian proton-coupled oligopeptide transporter PepT1 is recognised as an important route of oral drug delivery. Peptide-based compounds offer great potential as drugs but their application is limited by poor membrane permeability, amongst other challenges. Using cyclosporin A as a proof-of-concept, we demonstrate for the first time that peptidic molecules over 1000 Da in size can be targeted towards and transported by PepT1.
- Is Part Of:
- MedChemComm. Volume 7:Issue 5(2016:May)
- Journal:
- MedChemComm
- Issue:
- Volume 7:Issue 5(2016:May)
- Issue Display:
- Volume 7, Issue 5 (2016)
- Year:
- 2016
- Volume:
- 7
- Issue:
- 5
- Issue Sort Value:
- 2016-0007-0005-0000
- Page Start:
- 999
- Page End:
- 1002
- Publication Date:
- 2016-03-29
- Subjects:
- Pharmaceutical chemistry -- Periodicals
615.19 - Journal URLs:
- http://pubs.rsc.org/en/journals/journalissues/md ↗
http://www.rsc.org/ ↗ - DOI:
- 10.1039/c5md00575b ↗
- Languages:
- English
- ISSNs:
- 2040-2503
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 5424.685000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 2893.xml