Composites of Bacterial Cellulose and Small Molecule‐Decorated Gold Nanoparticles for Treating Gram‐Negative Bacteria‐Infected Wounds. Issue 27 (23rd May 2017)

• Record Type: Journal Article
• Authors: Li, Ying; Tian, Yue; Zheng, Wenshu; Feng, Yan; Huang, Rong; Shao, Jingxin; Tang, Rongbing; Wang, Peng; Jia, Yuexiao; Zhang, Jiangjiang; Zheng, Wenfu; Yang, Guang; Jiang, Xingyu
• Is Part Of: Small. Volume 13:Issue 27(2017)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2017-05-23
• Subjects: antibacterial -- Au‐DAPT NPs -- bacterial cellulose -- BC‐Au‐DAPT nanocomposites; Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.201700130
• Languages: English
• ISSNs: 1613-6810

Abstract

Abstract : Bacterial infections, especially multidrug‐resistant bacterial infections, are an increasingly serious problem in the field of wound healing. Herein, bacterial cellulose (BC) decorated by 4, 6‐diamino‐2‐pyrimidinethiol (DAPT)‐modified gold nanoparticles (Au‐DAPT NPs) is presented as a dressing (BC‐Au‐DAPT nanocomposites) for treating bacterially infected wounds. BC‐Au‐DAPT nanocomposites have better efficacy (measured in terms of reduced minimum inhibition concentration) than most of the antibiotics (cefazolin/sulfamethoxazole) against Gram‐negative bacteria, while maintaining excellent physicochemical properties including water uptake capability, mechanical strain, and biocompatibility. On Escherichia coli ‐ or Pseudomonas aeruginosa ‐infected full‐thickness skin wounds on rats, the BC‐Au‐DAPT nanocomposites inhibit bacterial growth and promote wound repair. Thus, the BC‐Au‐DAPT nanocomposite system is a promising platform for treating superbug‐infected wounds. Abstract : Bacterial cellulose (BC) decorated by 4, 6‐diamino‐2‐pyrimidinethiol (DAPT)‐modified Au nanoparticles (Au‐DAPT NPs) is presented as a dressing (BC‐Au‐DAPT NPs) for treating bacteria‐infected wounds. BC‐Au‐DAPT nanocomposites show excellent performance against multidrug‐resistant Gram‐negative bacteria. On the Escherichia coli‐ or Pseudomonas aeruginosa‐ infected model wounds on rats, the BC‐Au‐DAPT nanocomposites completely inhibit bacterial growth and promote the wound repair.