Pluripotent Stem Cell‐Based Platforms in Cardiac Disease Modeling and Drug Testing. Issue 2 (August 2017)

• Record Type: Journal Article
• Authors: Shaheen, N; Shiti, A; Gepstein, L
• Is Part Of: Clinical pharmacology & therapeutics. Volume 102:Issue 2(2017)
• Page Start: 203
• Page End: 208
• Publication Date: 2017-08
• Subjects: Pharmacology -- Periodicals; Therapeutics -- Periodicals; 615.5
• DOI: 10.1002/cpt.722
• Languages: English
• ISSNs: 0009-9236

Abstract

Abstract : The ability to generate patient/disease‐specific human pluripotent stem cell (hPSC)‐derived cardiomyocytes (hPSC‐CMs) brings a unique value to the fields of cardiac disease modeling, drug testing, drug discovery, and precision medicine. Further integration of emerging innovative technologies such as developmental‐biology inspired differentiation into chamber‐specific cardiomyocyte subtypes, genome‐editing, tissue‐engineering, and novel functional phenotyping methodologies should facilitate even more advanced investigations. Here, we review cornerstone concepts and recent highlights of hPSC‐based cardiac disease modeling and drug testing.