Composition, Antifungal and Antiproliferative Activities of the Hydrodistilled Oils from Leaves and Flower Heads of Pterocephalus nestorianus Nábělek. Issue 7 (27th May 2017)

• Record Type: Journal Article
• Authors: Abdullah, Fuad O.; Hussain, Faiq H. S.; Mannucci, Barbara; Lappano, Rosamaria; Tosi, Solveig; Maggiolini, Marcello; Vidari, Giovanni
• Is Part Of: Chemistry & biodiversity. Volume 14:Issue 7(2017)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2017-05-27
• Subjects: Pterocephalus nestorianus -- Dipsacaceae -- Kurdish folk medicine -- Oil composition -- Antifungal and antiproliferative activities; Biochemistry -- Periodicals; Molecular biology -- Periodicals; Biodiversity -- Periodicals; 572
• DOI: 10.1002/cbdv.201700009
• Languages: English
• ISSNs: 1612-1872

Abstract

Abstract : This article reports the first study of the chemical composition, and antifungal and antiproliferative properties of the volatile extracts obtained by hydrodistillation of the flower heads and leaves of the traditional Kurdish medicinal plant Pterocephalus nestorianus Nábělek, collected in the wild. A total of 55 constituents, 43 of the flower heads' oil (PFO) and 46 of the leaves' oil (PLO), respectively, were identified by GC/MS, constituting 99.68% and 99.04% of the two oils, respectively. The oils were obtained in 0.15% and 0.10% yields ( w / w ), respectively, on air‐dried vegetable material. The prevalent constituents of the PFO were α ‐terpineol (2.41%), α ‐linalool (6.42%), 6, 10, 14‐trimethylpentadecan‐2‐one (2.59%), myristic acid (24.65%), and lauric acid (50.44%), while the major components of PLO were ( E )‐hex‐2‐enal (2.26%), ( E )‐hex‐2‐en‐1‐ol (2.04), myristic acid (34.03%), and lauric acid (50.35%). The two oils showed significant inhibitory and fungicidal activities against the medically important fungi Candida albicans, Candida tropicalis, Microsporum canis, and Trichophyton mentagrophytes, with minimum inhibitory concentration ranging from 0.7 to 3.3 mg/ml and minimum fungicidal concentration varying from 1.4 to 6.6 mg/ml. The antiproliferative activity of the two oils was assayed against one normal and six human tumor cell lines. Both oils showed selective cytotoxic activity, with IC 50 values ranging from 1.4 to 3.3 μg/ml. Abstract :