A bioconjugate leveraging xenoreactive antibodies to alleviate cocaine-induced behavior12. Issue 58 (5th July 2017)

• Record Type: Journal Article
• Authors: Jacob, NIcholas T.; Anraku, Kensaku; Kimishima, Atsushi; Zhou, Bin; Collins, Karen C.; Lockner, Jonathan W.; Ellis, Beverley A.; Janda, Kim D.
• Is Part Of: Chemical communications. Volume 53:Issue 58(2017)
• Page Start: 8156
• Page End: 8159
• Publication Date: 2017-07-05
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c7cc04055e
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A bioconjugate targeted to prefromed, xenoreactive antibodies also containing a cocaine hapten elicits a potent and specific anti-cocaine response able to significantly attenuate cocaine-induced behavior. Abstract : A method for potentiating the response to an anti-cocaine vaccine by leveraging xenoreactive antibodies against the carbohydrate epitope Galα1, 3-Gal (GAL) was found to result in a highly specific anti-cocaine response that was able to significantly attenuate cocaine-induced locomotion at 20 mg kg −1 with superior efficacy compared to a standard conjugate.