A Unified Strategy Towards N‐Aryl Heterocycles by a One‐Pot Copper‐Catalyzed Oxidative C–H Amination of Azoles. Issue 27 (5th August 2014)

• Record Type: Journal Article
• Authors: Subramanian, Parthasarathi; Kaliappan, Krishna P.
• Is Part Of: European journal of organic chemistry. Issue 27(2014)
• Page Start: 5986
• Page End: 5997
• Publication Date: 2014-08-05
• Subjects: Synthetic methods -- C–H activation -- Amination -- Nitrogen heterocycles -- Copper -- Reaction mechanisms; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.201402868
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract: An efficient one‐pot synthesis of N ‐aryl‐substituted heterocycles by a Cu‐catalyzed two‐fold C–N bond formation is reported. This strategy involves a Cu I ‐catalyzed C–N bond‐forming reaction between azoles and electron‐deficient bromopyridines followed by an intramolecular sp 2 C–H amination. One of the products thus formed has been successfully used as a ligand for the synthesis of a Pd complex. Abstract : An efficient one‐pot synthesis of N ‐aryl heterocycles by a Cu‐catalysed double C–N bond formation is reported. This strategy involves a Cu I ‐catalysed C–N bond‐forming reaction between azoles and electron‐deficient bromopyridines followed by an intramolecular sp 2 C–H amination.