Fragmentation behavior of DOTA complexes under different activation conditions. (23rd June 2017)

• Record Type: Journal Article
• Authors: Beck, S.; Trog, S.; Knizia, S.; Linscheid, M. W.
• Is Part Of: Journal of mass spectrometry. Volume 52:Number 7(2017)
• Page Start: 442
• Page End: 451
• Publication Date: 2017-06-23
• Subjects: DOTA -- ESI -- CID -- HCD -- IRMPD; Mass spectrometry -- Periodicals; 543.65
• DOI: 10.1002/jms.3942
• Languages: English
• ISSNs: 1076-5174

Abstract

Abstract : We have investigated the fragmentation behavior of a number of DOTA‐metal complexes under collision‐induced dissociation, infrared‐multiphoton dissociation and higher‐energy collisional dissociation activation conditions. Both, positive and negative ion mode electrospray ionization was applied. The results show that characteristic fragmentations were obtained for the metal‐complexes under the investigated conditions. All elemental compositions of fragment ions have been unambiguously identified by high resolution‐accurate mass measurements. Certain trends, for instance eliminations of carbon dioxide, alkyl and amine residues, were observed that coincide with the size of the metal and its location within the periodic table. Additionally, lanthanide, aluminium and indium species with even oxidation state or containing a radical have been detected. To further investigate the observed water capture during activation, deuterium labeling experiments have also been carried out. Copyright © 2017 John Wiley & Sons, Ltd.