Oncolytic Maraba Virus MG1 as a Treatment for Sarcoma. Issue 6 (21st June 2017)

• Record Type: Journal Article
• Authors: Le Boeuf, Fabrice; Selman, Mohammed; Son, Hwan Hee; Bergeron, Anabel; Chen, Andrew; Tsang, Jovian; Butterwick, Derek; Arulanandam, Rozanne; Forbes, Nicole E.; Tzelepis, Fanny; Bell, John C.; Werier, Joel; Abdelbary, Hesham; Diallo, Jean‐Simon
• Is Part Of: International journal of cancer. Volume 141:Issue 6(2017:Sep. 15)
• Page Start: 1257
• Page End: 1264
• Publication Date: 2017-06-21
• Subjects: Cancer -- Periodicals; Cancer -- Prevention -- Periodicals; 616.994
• DOI: 10.1002/ijc.30813
• Languages: English
• ISSNs: 0020-7136

Abstract

Abstract : The poor prognosis of patients with advanced bone and soft‐tissue sarcoma has not changed in the past several decades, highlighting the necessity for new therapeutic approaches. Immunotherapies, including oncolytic viral (OV) therapy, have shown great promise in a number of clinical trials for a variety of tumor types. However, the effective application of OV in treating sarcoma still remains to be demonstrated. Although few pre‐clinical studies using distinct OVs have been performed and demonstrated therapeutic benefit in sarcoma models, a side‐by‐side comparison of clinically relevant OV platforms has not been performed. Four clinically relevant OV platforms (Reovirus, Vaccinia virus, Herpes‐simplex virus and Rhabdovirus) were screened for their ability to infect and kill human and canine sarcoma cell lines in vitro, and human sarcoma specimens ex vivo . In vivo treatment efficacy was tested in a murine model. The rhabdovirus MG1 demonstrated the highest potency in vitro . Ex vivo, MG1 productively infected more than 80% of human sarcoma tissues tested, and treatment in vivo led to a significant increase in long‐lasting cures in sarcoma‐bearing mice. Importantly, MG1 treatment induced the generation of memory immune response that provided protection against a subsequent tumor challenge. This study opens the door for the use of MG1‐based oncolytic immunotherapy strategies as treatment for sarcoma or as a component of a combined therapy. Abstract : What's new? The prognosis for advanced sarcoma remains poor, and new approaches to treatment are urgently needed. In this study of various oncolytic viral (OV) therapies, the authors found that a rhabdovirus called MG1 produced the most promising response in mice. In addition, MG1 treatment induced the generation of a memory immune response that provided protection against a subsequent tumor challenge. These results suggest that MG1‐based oncolytic immunotherapy may offer a promising treatment strategy for sarcoma, either alone or as a component of a combined therapy.