Population‐based cohort study of the effect of endometrial cancer classification and treatment criteria on long‐term survival. Issue 2 (8th June 2017)

• Record Type: Journal Article
• Authors: Svanvik, Teresia; Sundfeldt, Karin; Strömberg, Ulf; Holmberg, Erik; Marcickiewicz, Janusz
• Is Part Of: International journal of gynaecology and obstetrics. Volume 138:Issue 2(2017)
• Page Start: 183
• Page End: 189
• Publication Date: 2017-06-08
• Subjects: Adjuvant therapy -- Endometrial cancer -- Relative survival; Gynecology -- Periodicals; Obstetrics -- Periodicals; Electronic journals; 618
• DOI: 10.1002/ijgo.12214
• Languages: English
• ISSNs: 0020-7292

Abstract

Abstract: Objective: To evaluate if increased individualization in endometrial cancer classification/treatment affected relative survival. Methods: The present retrospective register‐based population study included data from all women in the western Swedish healthcare region who were treated for endometrial cancer between January 1, 1995, and December 31, 2011. Outcomes and prognostic data were retrieved from the western Swedish healthcare region's cancer and clinical endometrial cancer registries. Patients were stratified based on two different treatment programs (cohort 1 January 1, 1995, to September 10, 2006, and cohort 2 September 11, 2006, to December 31, 2011) and relative survival was compared. Results: Data from 4338 patients were included; 2936 in cohort 1 and 1402 in cohort 2. Among endometrioid endometrial carcinomas, the 5‐year relative survival rate for did not differ significantly between the groups ( P= 0.751); radiotherapy was used more frequently in cohort 1 ( P< 0.001). Among non‐endometrioid endometrial carcinomas, relative survival was lower in cohort 1 ( P= 0.006); radiotherapy use was more frequent in cohort 1 and chemotherapy use was more frequent in cohort 2 ( P< 0.001). Conclusion: Increased individualization in endometrioid endometrial cancer management did not improve relative survival. Improved relative survival was observed for non‐endometrioid endometrial cancer; possibly due to increased adjuvant chemotherapy use. Abstract : Increased individualization in classification and treatment was associated with improved relative survival in patients with non‐endometrioid adenocarcinoma but not in those with endometrioid adenocarcinoma.