Quantitative pretreatment CT volumetry: Association with oncologic outcomes in patients with T4a squamous carcinoma of the larynx. Issue 8 (2nd May 2017)

• Record Type: Journal Article
• Authors: Shiao, Jay C.; Mohamed, Abdallah S. R.; Messer, Jay A.; Hutcheson, Katherine A.; Johnson, Jason M.; Enderling, Heiko; Kamal, Mona; Warren, Benjamin W.; Pham, Brian; Morrison, William H.; Zafereo, Mark E.; Hessel, Amy C.; Lai, Stephen Y.; Kies, Merril S.; Ferrarotto, Renata; Garden, Adam S.; Schomer, Donald F.; Gunn, G. Brandon; Phan, Jack; Frank, Steven J.; Beadle, Beth M.; Weber, Randal S.; Lewin, Jan S.; Rosenthal, David I.; Fuller, Clifton D.
• Is Part Of: Head & neck. Volume 39:Issue 8(2017)
• Page Start: 1609
• Page End: 1620
• Publication Date: 2017-05-02
• Subjects: outcomes -- radiotherapy -- survival -- T4a -- tumor -- volume -- volumetry; Head -- Diseases -- Periodicals; Neck -- Diseases -- Periodicals; Head -- Periodicals; Neck -- Periodicals; Face -- Periodicals; 617.51059
• DOI: 10.1002/hed.24804
• Languages: English
• ISSNs: 1043-3074

Abstract

Abstract: Background: The purpose of this study was to determine the impact of CT‐determined pretreatment primary tumor volume on survival and disease control in T4a laryngeal squamous cell carcinoma (SCC). Methods: We retrospectively reviewed 124 patients with T4a laryngeal cancer from 2000‐2011. Tumor volume measurements were collected and correlated with outcomes. Results: Five‐year overall survival (OS) for patients with tumor volume ≥21 cm 3 treated with larynx preservation (n = 26 of 41) was significantly inferior compared to <21 cm 3 (42% vs 64%, respectively; P = .003). Five‐year OS for patients with tumor volumes ≥21 cm 3 in the cohort treated with total laryngectomy followed by radiotherapy (RT; n = 42 of 83) was not statistically significant when compared to <21 cm 3 (50% vs 63%, respectively; P = .058). On multivariate analysis, tumor volume ≥21 cm 3 was a significant independent correlate of worse disease‐specific survival (DSS; P = .004), event‐free survival ( P = .005), recurrence‐free survival (RFS; P = .04), noncancer cause‐specific survival ( P = .02), and OS ( P = .0002). Conclusion: Pretreatment CT‐based tumor volume is an independent prognostic factor of outcomes in T4a laryngeal cancer.