Dicationic Ruthenium(II)–Arene–Curcumin Complexes Containing Methylated 1, 3, 5‐Triaza‐7‐phosphaadamantane: Synthesis, Structure, and Cytotoxicity. Issue 22 (14th June 2017)

• Record Type: Journal Article
• Authors: Pettinari, Riccardo; Condello, Francesca; Marchetti, Fabio; Pettinari, Claudio; Smoleński, Piotr; Riedel, Tina; Scopelliti, Rosario; Dyson, Paul J.
• Is Part Of: European journal of inorganic chemistry. Issue 22(2017)
• Page Start: 2905
• Page End: 2910
• Publication Date: 2017-06-14
• Subjects: Curcumin -- Bisdemethoxycurcumin -- Arene ligands -- Ruthenium -- Cytotoxicity -- Antitumor agents; Chemistry, Inorganic -- Periodicals; Organometallic chemistry -- Periodicals; Bioinorganic chemistry -- Periodicals; Solid state chemistry -- Periodicals; 546
• DOI: 10.1002/ejic.201700183
• Languages: English
• ISSNs: 1434-1948

Abstract

Abstract : Dicationic ruthenium(II)– p ‐cymene complexes containing curcumin ligands (curcH = curcumin, bdcurcH = bisdemethoxycurcumin) and ionic N ‐methyl‐1, 3, 5‐triaza‐7‐phosphaadamantane [PTA‐Me]X (X = BF4 or I) have been synthesized and fully characterized for the first time. The solid‐state structure of [Ru( p ‐cym)(curc)(PTA‐Me)][SO3 CF3 ][BF4 ] has also been determined by single‐crystal X‐ray diffraction. Modest antiproliferative activities of the complexes were observed against cisplatin‐sensitive and cisplatin‐resistant human ovarian carcinoma cells (A2780 and A2780cisR, respectively) and nontumorigenic human embryonic kidney (HEK293) cells. Abstract : Water‐soluble dicationic arene–Ru II curcumin complexes with methylated 1, 3, 5‐triaza‐7‐phosphaadamantane (PTA) have been structurally characterized and display modest cytotoxicity in vitro against human ovarian carcinoma A2780 and A2780cisR cells.