Advanced Electrochemical Scaffolds for Multiplexed Biosensing of Cancer Reporters in Complex Clinical Samples. (2017)

• Record Type: Journal Article
• Authors: Torrente-Rodríguez, Rebeca M.; Campuzano, Susana; Montiel, Víctor Ruiz-Valdepeñas; Eletxigerra, Unai; Martinez-Perdiguero, Josu; Merino, Santos; Barderas, Rodrigo; Villalonga, Reynaldo; Pingarrón, José M.
• Is Part Of: Procedia technology. Volume 27(2016)
• Page Start: 17
• Page End: 20
• Publication Date: 2017
• Subjects: multiplexed -- electrochemical scaffolds -- cancer biomarkers -- clinical samples; Technology -- Congresses; Technology -- Periodicals; Engineering -- Congresses; Engineering -- Periodicals; Engineering; Technology; Conference proceedings; Periodicals; 605
• DOI: 10.1016/j.protcy.2017.04.010
• Languages: English
• ISSNs: 2212-0173

Abstract

Abstract: Early and reliable diagnostic of cancer is mandatory to increase patient survival, thus requiring efficient and reliable analytical methods for such a purpose. Within this context, different strategies implying the development of electrochemical biosensors for the sensitive, selective and rapid multiplexed biosensing of genetic or protein cancer-related biomarkers are addressed in this presentation. In particular, novel sensing platforms have been developed for the determination of miRs, interleukin (IL)-8 mRNA, IL-8 protein, and cancer specific receptors. The developed methodologies allow for the determination of the target analytes at clinically relevant levels in complex samples: cancer cells, human tissues cell lysates, serum and raw saliva and can be easily extended to the determination of other relevant biomarkers.