D-dimer Quantification from Autologous Red Blood Cells Agglutination by a Lens-free Imaging Device. (2017)

• Record Type: Journal Article
• Authors: Huet, M.; Cubizolles, M.; Pouteau, P.; Poher, V.; Buhot, A.
• Is Part Of: Procedia technology. Volume 27(2016)
• Page Start: 167
• Page End: 168
• Publication Date: 2017
• Subjects: Red blood cells agglutination -- D-dimer quantification -- lens-free detection; Technology -- Congresses; Technology -- Periodicals; Engineering -- Congresses; Engineering -- Periodicals; Engineering; Technology; Conference proceedings; Periodicals; 605
• DOI: 10.1016/j.protcy.2017.04.073
• Languages: English
• ISSNs: 2212-0173

Abstract

Abstract: Quantification of biomarkers closest to the patient remains an impressive challenge for the development of personalized medicine. The detection of D-dimer, a fibrin degradation product, indicative of deep vein thrombosis, pulmonary embolism or stroke is a particular biomarker of interest. In this study, we developed a quantitative assay based on the measurement of autologous red blood cells agglutination by a lens-free device. An indicator, obtained from the shape of the gray level histogram of the images, allows us for a linear quantification of D-dimer opening the door for a Point-of-Care device.