Association of alirocumab therapy with inflammatory lesions of the vocal folds: A case report. (9th December 2016)

• Record Type: Journal Article
• Authors: Benedict, Peter A.; Abdou, Rania M.; Dion, Gregory R.; Woo, Peak; Branski, Ryan C.; Amin, Milan R.
• Is Part Of: Laryngoscope. Volume 127:Number 7(2017)
• Page Start: 1652
• Page End: 1654
• Publication Date: 2016-12-09
• Subjects: Larynx -- monoclonal antibody -- laryngeal lesion -- alirocumab -- adverse effect; Otolaryngology -- Periodicals; 617.51005
• DOI: 10.1002/lary.26426
• Languages: English
• ISSNs: 0023-852X

Abstract

Abstract : Therapeutic monocolonal antibodies (MAbs) are a new, rapidly growing class of medications that frequently have poorly characterized side‐effect profiles. We present a patient who developed inflammatory lesions of the vocal folds in temporal relation to the initiation of alirocumab. Lesions of the vocal folds represent a previously unreported adverse effect of alirocumab therapy, making it the second MAb documented with such a side effect. The potential laryngeal effects of alirocumab specifically, and of MAbs more broadly, warrant investigation. Laryngoscope, 127:1652–1654, 2017