Simultaneously increased expression of microRNA‐155 and suppressor of cytokine signaling 1 (SOCS1) gene in the peripheral blood mononuclear cells of patients with primary Sjögren's syndrome. (1st December 2015)

• Record Type: Journal Article
• Authors: Chen, Ji‐Qing; Zilahi, Erika; Papp, Gábor; Sipka, Sándor; Zeher, Margit
• Is Part Of: International journal of rheumatic diseases. Volume 20:Number 5(2017)
• Page Start: 609
• Page End: 613
• Publication Date: 2015-12-01
• Subjects: microRNA‐155 (miR‐155) -- primary Sjögren's syndrome (pSS) -- suppressor of cytokine signaling 1 (SOCS1); Rheumatology -- Periodicals; Rheumatology -- Asia -- Periodicals; Rheumatology -- Pacific Area -- Periodicals; Rheumatic Diseases -- Periodicals; Connective Tissue Diseases -- Periodicals; Immune System Diseases -- Periodicals; 616.723
• DOI: 10.1111/1756-185X.12804
• Languages: English
• ISSNs: 1756-1841

Abstract

Abstract: Aim: The microRNA‐155 (miR‐155) is regarded as a central modulator of T‐cell responses and could be a potential therapeutic target for certain inflammatory diseases. In our present study we analyzed the expression rate of miR‐155 and its functionally linked gene, the suppressor gene of cytokine signaling 1 ( SOCS1 ) in primary Sjögren's syndrome (pSS). Method: We enrolled 23 pSS patients and 10 healthy individuals in the study. The expression of miR‐155 and SOCS1 gene were measured by real‐time polymerase chain reaction. Results: We observed the over‐expression of miR‐155 in the peripheral mononuclear cells of patients with pSS. Surprisingly, SOCS1 gene was also over‐expressed in pSS patients. Conclusion: This unanticipated phenomenon might be a laboratory characteristic of Sjögren's syndrome, and presumably a consequence of the noteworthy difference in the pSS immune system reacting with Epstein–Barr virus.