Antagomirs and microRNA in status epilepticus. (3rd September 2013)

• Record Type: Journal Article
• Authors: Henshall, David C.
• Is Part Of: Epilepsia. Volume 54(2013)Supplement 6
• Page Start: 17
• Page End: 19
• Publication Date: 2013-09-03
• Subjects: Epilepsy -- Epileptogenesis -- Hippocampal sclerosis -- Noncoding RNA; Epilepsy -- Periodicals; 616.853
• DOI: 10.1111/epi.12267
• Languages: English
• ISSNs: 0013-9580

Abstract

Summary: MicroRNAs are an important class of noncoding RNA, which function as posttranscriptional regulators of protein levels within cells. Emerging work has revealed that status epilepticus produces select changes to microRNA levels within the brain, which may impact levels of proteins involved in neuronal structure and excitability, gliosis, inflammation, and apoptosis. Animal studies show that targeting microRNAs using locked nucleic acid–modified oligonucleotides ("antagomirs") can have potent effects on status epilepticus, seizure‐induced neuronal death, and the later emergence of recurrent spontaneous seizures. Accordingly, microRNA‐based therapeutics may have potential as a future treatment of status epilepticus.