Olive phenolic compounds attenuate deltamethrin-induced liver and kidney toxicity through regulating oxidative stress, inflammation and apoptosis. (August 2017)

• Record Type: Journal Article
• Authors: Maalej, Amina; Mahmoudi, Asma; Bouallagui, Zouhaier; Fki, Ines; Marrekchi, Rim; Sayadi, Sami
• Is Part Of: Food and chemical toxicology. Volume 106:Part A(2017)
• Page Start: 455
• Page End: 465
• Publication Date: 2017-08
• Subjects: Olive fruit extract -- Oleuropein -- Deltamethrin -- Hepato-renal toxicity; Toxicology -- Periodicals; Food poisoning -- Periodicals; Food Poisoning -- Periodicals; Toxicology -- Periodicals; Toxicologie -- Périodiques; Intoxications alimentaires -- Périodiques; Food poisoning; Toxicology; Periodicals; Electronic journals; 615.9
• DOI: 10.1016/j.fct.2017.06.010
• Languages: English
• ISSNs: 0278-6915

Abstract

Abstract: The purpose of this study was to evaluate the protective effect of ethanolic olive fruit extract (OFE) and its phenolic compound, oleuropein (OLE), against hepato-renal toxicity induced by deltamethrin (DEM), a synthetic pyrethroid, in Wistar rats. The kidney and liver tissues were collected after 30 days of treatment for subsequent investigation. Rats that were given DEM had a highly significant elevation in the serum biomarkers as well as hepatic and renal levels of lipid peroxidation (MDA). Additionally, a significant reduction in the total antioxidant capacity (ABTS+), superoxide dismutase (SOD) and catalase (CAT) activities was noted. This toxic effect was confirmed by histological studies and the expression levels of inflammatory (cox-2) and apoptotic genes (bcl-2 and p53). The findings for the OFE and OLEtreated groups highlighted the efficacy of olive fruit phenolic compounds as hepatic and renal-protectant in DEM-induced hepato-renal toxicity through improving the oxidative status as well as suppressing inflammation and apoptosis. Therefore, they may be used as protective natural compounds against DEM-induced hepato-renal toxicity. Graphical abstract: Highlights: The administration of deltamethrin (DEM) to rats for 30 days induced hepato-renal toxicity. Olive fruit extract (OFE) and oleuropein (OLE) administration improved serum and liver biomarkers. OFE and OLE reduced the DEM-induced decrease in total antioxidant, superoxide dismutase and catalase activities. OFE and OLE improved the expression of cox-2, bcl-2 and p53 proteins in renal and hepatic tissues.