Coatings in food contact materials: Potential source of genotoxic contaminants?. (August 2017)

• Record Type: Journal Article
• Authors: Mertens, Birgit; Van Bossuyt, M.; Fraselle, S.; Blaude, M.N.; Vanhaecke, T.; Rogiers, V.; Verschaeve, L.; Van Hoeck, E.
• Is Part Of: Food and chemical toxicology. Volume 106:Part A(2017)
• Page Start: 496
• Page End: 505
• Publication Date: 2017-08
• Subjects: DNA damage -- ECHA database -- Food contact materials -- In silico -- Prioritization strategy -- Structure-activity relationship; BADGE bisphenol A diglycidyl ether -- BFDGE bisphenol F diglycidyl ether -- CHL Chinese hamster lung -- CLP Classification, Labelling and Packaging -- CoE Council of Europe -- CoRAP Community rolling action plan -- ECHA European CHemicals Agency -- EFSA European Food Safety Authority -- EU European Union -- FCM food contact materials -- IARC International Agency for Research on Cancer -- NOGE novolac glycidyl ether -- NTP National Toxicology Program -- RAC Risk Assessment Committee -- REACH Registration, Evaluation, Authorisation and Restriction of Chemicals -- SA structural alert -- SCCP Scientific Committee on Consumer Products -- SCCS Scientific Committee on Consumer Safety -- SCHER Scientific Committee on Health and Environmental Risks -- SCF Scientific Committee on Food -- SMILES Simplified Molecular Input Line Entry System -- SML specific migration limit -- WHO World Health Organisation; Toxicology -- Periodicals; Food poisoning -- Periodicals; Food Poisoning -- Periodicals; Toxicology -- Periodicals; Toxicologie -- Périodiques; Intoxications alimentaires -- Périodiques; Food poisoning; Toxicology; Periodicals; Electronic journals; 615.9
• DOI: 10.1016/j.fct.2017.05.071
• Languages: English
• ISSNs: 0278-6915

Abstract

Abstract: Up till now, no harmonized EU regulation exists on chemicals used in coatings for food contact materials (FCM). Therefore, these substances need to comply with the general provisions of EU Regulation 1935/2004 and, if present, with national legislation. Different 'inventory lists' of compounds that might be present in coatings are available, but for hundreds of these substances, the potential human health impact of their use in FCM coatings has not (recently) been evaluated. Since detailed evaluation of all compounds is not feasible, a pragmatic approach was developed to identify substances with a potential concern for human health. First, an inventory was assembled containing all substances potentially used in coatings. Afterwards, the genotoxic potential of the non-evaluated substances was predicted in silico using two structure-activity relationship (SAR) software programs. For substances yielding structural alerts in both models, genotoxicity data were collected from previous European evaluations in a non-FCM context and from the European CHemicals Agency (ECHA) website. In total, 53 substances were identified as genotoxic in both in silico models, of which ten were considered to be of high concern. For most of the substances, additional toxicological information is needed. Highlights: 1976 substances with no (recent) toxicological evaluation may be used in coatings. 53 substances are predicted genotoxic in both ToxTree and Derek Nexus™. 10 high concern substances based on in vivo genotoxicity and/or CMR classification. Urgent need to investigate actual use of ten high concern substances in coatings.