Highly Efficient Curtius Rearrangement Approach for the Synthesis of Unsymmetrical Sulfonimidoyl Ureas. Issue 7 (1st June 2017)

• Record Type: Journal Article
• Authors: Zhou, Hao; Hong, Jianquan; Huang, Jiapian; Chen, Zhiyuan
• Is Part Of: Asian journal of organic chemistry. Volume 6:Issue 7(2017)
• Page Start: 817
• Page End: 820
• Publication Date: 2017-06-01
• Subjects: Curtius rearrangement -- metal-free synthesis -- sulfoximine derivatives -- unsymmetrical ureas; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; 547.005
• DOI: 10.1002/ajoc.201700248
• Languages: English
• ISSNs: 2193-5807

Abstract

Abstract: A highly efficient synthesis of unsymmetrical sulfoximine ureas is developed. The reaction unites simple N H‐sulfoximines and acyl azides by a formal Curtius rearrangement as the key step. This reaction could be easily scaled up to gram scale and omits the generation of hazardous byproducts, thus allowing a practical and environmentally benign path for the synthesis of medicinally important sulfonimidoyl unsymmetrical ureas. Abstract : A highly efficient synthesis of unsymmetrical sulfoximine ureas has been developed. The reaction unites simple N H‐sulfoximines and acyl azides by a formal Curtius rearrangement as the key step. This reaction omits the generation of hazardous byproducts and could be easily scaled up to gram scale, thus allowing a practical and environmentally benign path for the synthesis of medicinally important sulfonimidoyl unsymmetrical ureas.