Periconiasin G, a new cytochalasan with unprecedented 7/6/5 tricyclic ring system from the endophytic fungus Periconia sp. Issue 7 (17th February 2016)

• Record Type: Journal Article
• Authors: Zhang, Dewu; Tao, Xiaoyu; Liu, Jimei; Chen, Ridao; Zhang, Min; Li, Li; Fang, Xiaomei; Yu, Li-Yan; Dai, Jungui
• Is Part Of: Tetrahedron letters. Volume 57:Issue 7(2016)
• Page Start: 796
• Page End: 799
• Publication Date: 2016-02-17
• Subjects: Periconia -- Endophytic fungus -- Cytochalasan -- Periconiasin; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2016.01.030
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Abstract: Two new cytochalasans, periconiasin G (1 ) and periconiasin H (2 ) were isolated from endophytic fungus Periconia sp. F-31. Compound1 is the first cytochalasan with a 7/6/5 tricyclic ring system, and compound2 possesses a rare sulfoxide group. Their structures including absolute configurations were elucidated by extensive spectroscopic analyses and ECD calculations. A possible biogenetic pathway for these two compounds was proposed. Compound1 showed weak anti-HIV activity with IC50 value of 67.0 μM.