Repair of volumetric bone defects with a high strength BMP-loaded-mineralized hydrogel tubular scaffold. Issue 28 (5th July 2017)

• Record Type: Journal Article
• Authors: Zhang, Xuran; Xu, Bing; Gao, Fei; Zheng, Pengbin; Liu, Wenguang
• Is Part Of: Journal of materials chemistry. Volume 5:Issue 28(2017)
• Page Start: 5588
• Page End: 5596
• Publication Date: 2017-07-05
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c7tb01279a
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : A high strength and BMP-2-loaded tubular scaffold was engineered by in situ mineralization of a supramolecular hydrogel. This tubular scaffold could lead to an efficient volumetric bone repair. Abstract : Efficient repair of critical-size volumetric bone defects remains a challenge due to the additional complicated surgery required for fixation. In this work, we first synthesized hydrogen bonding crosslinked supramolecular polymer (SP) hydrogels termed as P(NAGA-VPA) by copolymerizing two carefully selected monomers, N -acryloyl glycinamide (hydrogen bonding monomer) and vinylphosphonic acid (mineralization active monomer) directly in a concentrated aqueous solution. The P(NAGA-VPA) hydrogels were then subjected to in situ precipitation mineralization to generate novel high strength mineralized SP hydrogels. The concerted dual physical crosslinkages of NAGA H-bonds and nanocrystal–polymer interaction led to the best comprehensive mechanical performances with a tensile strength of over 1 MPa and a compressive strength of 5 MPa in an equilibrium swelling state. The mineralized SP hydrogel tubular scaffold was fabricated and encapsulated with bone morphogenetic protein-2 (BMP-2). The BMP-2-loaded mineralized SP hydrogel tube was finely sleeved over the murine radial defect without resorting to any additional surgical fixation. The outcome of 8-weeks implantation demonstrated that this hybrid tubular scaffold contributed to an efficient repair of volumetric bone defect by accelerating new bone formation and seamlessly bonding to the bone surface.