Dual visible-light photoredox and palladium(ii) catalysis for dehydrogenative C2-acylation of indoles at room temperature. Issue 28 (6th July 2017)

• Record Type: Journal Article
• Authors: Manna, Manash Kumar; Bairy, Gurupada; Jana, Ranjan
• Is Part Of: Organic & biomolecular chemistry. Volume 15:Issue 28(2017)
• Page Start: 5899
• Page End: 5903
• Publication Date: 2017-07-06
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c7ob01418j
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A mild protocol for direct C2-acylation of indoles with aldehydes is reported at room temperature through the merger of visible light photoredox and palladium(ii ) catalysis. Late-stage acylation of tryptophan and selective mono-acylation of carbazoles are also demonstrated. Abstract : A highly regioselective direct C2-acylation of N -pyrimidine protected indoles with aldehydes is reported at room temperature through the merger of visible light photoredox and palladium(ii ) catalysis. Late-stage acylation of tryptophan, selective mono-acylation of carbazole and the syntheses of tubulin inhibitors D-64131 and D-68144 are also demonstrated.