Frontispiece: Sulfur–Fluoride Exchange (SuFEx)‐Mediated Synthesis of Sterically Hindered and Electron‐Deficient Secondary and Tertiary Amides via Acyl Fluoride Intermediates. Issue 42 (26th July 2017)

• Record Type: Journal Article
• Authors: Smedley, Christopher J.; Barrow, Andrew S.; Spiteri, Christian; Giel, Marie‐Claire; Sharma, Pallavi; Moses, John E.
• Is Part Of: Chemistry. Volume 23:Issue 42(2017)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2017-07-26
• Subjects: acyl fluoride -- fluorides -- amides -- SuFEx click chemistry -- sulfur; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201784262
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract : The development of "SuFExAmide" : A new sulfur–fluoride exchange (SuFEx) click chemistry based protocol for the efficient amidation of carboxylic acids via acyl fluoride intermediates is described. Benzene‐1, 3‐disulfonyl fluoride has been synthesized as a cost effective, powerful and versatile coupling agent, which delivers challenging secondary and tertiary amides in excellent yields from sterically hindered and electron‐deficient amines. For more details, see the Communication by J. E. Moses et al onpage 9990 ff.