Synthesis and Biological Activity of Triazole‐Appended N, O‐Nucleosides1. Issue 25 (15th May 2014)

• Record Type: Journal Article
• Authors: Romeo, Roberto; Giofrè, Salvatore V.; Carnovale, Caterina; Chiacchio, Maria A.; Campisi, Agata; Mancuso, Raffaella; Cirmi, Santa; Navarra, Michele
• Is Part Of: European journal of organic chemistry. Issue 25(2014)
• Page Start: 5442
• Page End: 5447
• Publication Date: 2014-05-15
• Subjects: Nucleosides -- Triazoles -- Click chemistry -- Biological activity -- Antitumor agents; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.201402106
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract: 1, 2, 3‐Triazole‐appended N, O‐nucleosides have been synthesized by an approach combining a 1, 3‐dipolar cycloaddition process and an alkyne–azide click chemistry reaction. Biological assays, performed on six tumor cell lines, revealed the antiproliferative activity of the synthesized compounds. The effect was more evident in the U87MG human glioblastoma cell line. Thus, these nucleoside analogues could be promising scaffolds for the construction of new anticancer agents. Abstract : 1, 2, 3‐Triazole‐appended N, O‐nucleosides have been synthesized by an approach combining a 1, 3‐dipolar cycloaddition and an alkyne–azide click chemistry reaction. The synthesized compounds showed antiproliferative activity against tumor cell lines. These nucleoside analogues could be promising scaffolds for the construction of new anticancer agents.