A Novel Non-invasive Biosensor Based on Electric Field Detection for Cardio-electrophysiology in Zebrafish Embryos. (2017)

• Record Type: Journal Article
• Authors: Rendon-Morales, E.; Prance, R.J.; Prance, H.; Aviles-Espinosa, R.
• Is Part Of: Procedia technology. Volume 27(2016)
• Page Start: 242
• Page End: 243
• Publication Date: 2017
• Subjects: Bioelectronics -- Biological sensing -- Biosensors -- Cardiovascular systems -- Electrode Potentials -- Electrophysiology; Technology -- Congresses; Technology -- Periodicals; Engineering -- Congresses; Engineering -- Periodicals; Engineering; Technology; Conference proceedings; Periodicals; 605
• DOI: 10.1016/j.protcy.2017.04.103
• Languages: English
• ISSNs: 2212-0173

Abstract

Abstract: In this paper we report a novel biosensor based on electric field detection for recording cardiac electrical activity in zebrafish embryos. Using Sussex patented Electric Potential Sensing technology, a portable, non-invasive and cost-effective platform is developed to monitor in vivo electrocardiogram activity from the zebrafish heart. Cardiac activity signals were successfully detected from living zebrafish embryos starting at 3 days-post-fertilization. The recorded waveforms contain typical traces such present in electrocardiogram, such as the QRS complex, P and T waves. This research opens new pathways for investigating cardiac related pathologies present at embryonic stages using a novel non-invasive biosensor.