Cancer cell targeting driven by selective polyamine reactivity with glycine propargyl esters. Issue 60 (7th June 2017)

• Record Type: Journal Article
• Authors: Vong, Kenward K. H.; Tsubokura, Kazuki; Nakao, Yoichi; Tanei, Tomonori; Noguchi, Shinzaburo; Kitazume, Shinobu; Taniguchi, Naoyuki; Tanaka, Katsunori
• Is Part Of: Chemical communications. Volume 53:Issue 60(2017)
• Page Start: 8403
• Page End: 8406
• Publication Date: 2017-06-07
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c7cc01934c
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Glycine propargyl ester reactivity shows evidence for selective polyamine reactivity, leading to a new strategy for cancer cell targeting. Abstract : Rapidly growing cancer cells have increased levels of intracellular polyamines compared to normal, healthy tissues. Based on the selective reactivity of glycine propargyl esters, probes were synthesized that show evidence for selective polyamine reactivity, which was then applied for selective cancer cell imaging studies.