Mexiletine co-injected with clonidine increases the quality and duration of cutaneous analgesia in response to skin pinpricks in the rat. (27th July 2017)

• Record Type: Journal Article
• Authors: Han, Ming-Ming; Chiu, Chong-Chi; Wang, Jhi-Joung; Chen, Yu-Wen; Hung, Ching-Hsia
• Is Part Of: Neuroscience letters. Volume 654(2017)
• Page Start: 23
• Page End: 27
• Publication Date: 2017-07-27
• Subjects: Clonidine -- Mexiletine -- Co-administration -- Infiltrative cutaneous analgesia -- Pinpricks; Neurology -- Periodicals; Neurology -- Periodicals; Research -- Periodicals; Neurologie -- Périodiques; Neuroanatomie -- Périodiques; Neuropharmacologie -- Périodiques; Neurophysiologie -- Périodiques; Neurology; Periodicals; Electronic journals; 617.48
• DOI: 10.1016/j.neulet.2017.06.022
• Languages: English
• ISSNs: 0304-3940

Abstract

Highlights: Subcutaneous mexiletine provoked dose-dependent cutaneous analgesia. Clonidine increased the potency of cutaneous analgesia by mexiletine. Mexiletine co-injected with clonidine prolonged the sensory block duration. Abstract: The goal of the experimental design was to assess the cutaneous analgesic effect of mexiletine by co-injection with clonidine. The effect of nociceptive block was evaluated according to the inhibition of the cutaneous trunci muscle reflex (CTMR) in response to skin pinpricks in rats. The dose-related analgesic effect of mexiletine alone or mexiletine co-administrated with clonidine was constructed after subcutaneous injection. Subcutaneous injections of mexiletine elicited dose-related cutaneous analgesia. Compared with mexiletine (1.8 μmol), adding clonidine to mexiletine (1.8 μmol) solutions for skin nociceptive block potentiated and prolonged the action ( p < 0.01). Mexiletine (6 μmol) combined with clonidine extended the duration of cutaneous analgesia when compared with mexiletine (6 μmol) alone ( p < 0.01). Co-administration of clonidine increases the potency and extends the duration of cutaneous analgesia by mexiletine, and the minimal dose of clonidine to intensify the analgesic effect is 0.06 μmol.