Bladder afferent hyperexcitability in bladder pain syndrome/interstitial cystitis. (April 2014)

• Record Type: Journal Article
• Authors: Yoshimura, Naoki; Oguchi, Tomohiko; Yokoyama, Hitoshi; Funahashi, Yasuhito; Yoshikawa, Satoru; Sugino, Yoshio; Kawamorita, Naoki; Kashyap, Mahendra P; Chancellor, Michael B; Tyagi, Pradeep; Ogawa, Teruyuki
• Is Part Of: International journal of urology. Volume 21(2014)Supplement 1
• Page Start: 18
• Page End: 25
• Publication Date: 2014-04
• Subjects: afferent pathway -- bladder pain syndrome -- cytokine -- interstitial cystitis -- nerve growth factor; Urology -- Periodicals; Genitourinary organs -- Periodicals; Urologic Diseases -- Periodicals; 616.6005
• DOI: 10.1111/iju.12308
• Languages: English
• ISSNs: 0919-8172

Abstract

Abstract: Bladder pain syndrome/interstitial cystitis is a disease with lower urinary tract symptoms, such as bladder pain and urinary frequency, which results in seriously impaired quality of life of patients. The extreme pain and urinary frequency are often difficult to treat. Although the etiology of bladder pain syndrome/interstitial cystitis is still not known, there is increasing evidence showing that afferent hyperexcitability as a result of neurogenic bladder inflammation and urothelial dysfunction is important to the pathophysiological basis of symptom development. Further investigation of the pathophysiology will lead to the effective treatment of patients with bladder pain syndrome/interstitial cystitis.