Structural diversity and chemical synthesis of peroxide and peroxide-derived polyketide metabolites from marine sponges. Issue 7 (10th May 2016)

• Record Type: Journal Article
• Authors: Norris, Matthew D.; Perkins, Michael V.
• Is Part Of: Natural product reports. Volume 33:Issue 7(2016:Jul.)
• Page Start: 861
• Page End: 880
• Publication Date: 2016-05-10
• Subjects: Natural products -- Periodicals; Produits naturels -- Périodiques; 547.7
• DOI: 10.1039/c5np00142k
• Languages: English
• ISSNs: 0265-0568

Abstract

Abstract : The structural elucidation, chemical synthesis and therapeutic potential of peroxide and peroxide-derived sponge metabolites, with special focus on their intriguing structural similarities and differences from a biogenetic perspective, are reviewed. Abstract : Covering: up to early 2016 Marine sponges are widely known as a rich source of natural products, especially of polyketide origin, with a wealth of chemical diversity. Within this vast collection, peroxide and peroxide-derived secondary metabolites have attracted significant interest in the fields of natural product isolation and chemical synthesis for their structural distinction and promising in vitro antimicrobial and anticancer properties. In this review, peroxide and peroxide-derived polyketide metabolites isolated from marine sponges in the past 35 years are summarised. Efforts toward their synthesis are detailed with a focus on methods that utilise or attempt to elucidate the complex biosynthetic interrelationships of these compounds beyond enzymatic polyketide synthesis. Recent isolations, advances in synthetic methodology and theories of biogenesis are highlighted and critically evaluated.