A Novel Pd‐Catalysed Annulation Reaction for the Syntheses of Pyrroloindoles and Pyrroloquinolines. Issue 1 (25th November 2015)

• Record Type: Journal Article
• Authors: Dethe, Dattatraya H.; Boda, Raghavender
• Is Part Of: Chemistry. Volume 22:Issue 1(2016)
• Page Start: 106
• Page End: 110
• Publication Date: 2015-11-25
• Subjects: alkynes -- annulation -- cyclization -- heterocycles -- palladium; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201503652
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract: Pd‐catalysed annulation reactions between indole derivatives and internal alkyne esters leading to various pyrrolo[1, 2‐ a ]indoles and pyrroloquinolines have been developed. The strategy involves an intermolecular addition of the indole nitrogen on to the internal alkyne ester followed by an intramolecular insertion of a vinyl–palladium complex into the carbonyl group. This method offers a facile and practical approach to pyrrolo[1, 2‐ a ]indoles and pyrroloquinolines. Abstract : One‐pot recipe! Pd‐catalysed annulation reactions between indole derivatives and internal alkyne esters leading to various pyrrolo[1, 2‐ a ]indoles and pyrroloquinolines have been developed (see scheme). The strategy involves an intermolecular addition of the indole nitrogen on to the internal alkyne ester followed by an intramolecular insertion of a vinyl–palladium complex into the carbonyl group.