Discovery of recurring behavioural sequences in Wistar rat social activity: Possible support to studies on Autism Spectrum Disorders. (13th July 2017)

• Record Type: Journal Article
• Authors: Casarrubea, M.; Faulisi, F.; Cudia, A.; Cancemi, D.; Cardaci, M.; Magnusson, M.S.; Crescimanno, G.
• Is Part Of: Neuroscience letters. Volume 653(2017)
• Page Start: 58
• Page End: 63
• Publication Date: 2017-07-13
• Subjects: Social behaviour -- Temporal structure -- T-pattern analysis -- Open field -- Wistar rat -- ASDs; Neurology -- Periodicals; Neurology -- Periodicals; Research -- Periodicals; Neurologie -- Périodiques; Neuroanatomie -- Périodiques; Neuropharmacologie -- Périodiques; Neurophysiologie -- Périodiques; Neurology; Periodicals; Electronic journals; 617.48
• DOI: 10.1016/j.neulet.2017.05.031
• Languages: English
• ISSNs: 0304-3940

Abstract

Graphical abstract: T-pattern analysis, applied to the study of social interaction in rats, revealing the existence of four different categories of qualitatively different t-patterns. Highlights: T-pattern analysis was applied to interactions of Wistar rats tested in open field. Recurring sequences of events were identified in rat interactive behaviour. 221 different t-patterns classified in four different categories were evidenced. T-patterns analysis may represent a potential aid for the study of ASDs. Abstract: This study was undertaken to investigate whether, in rat interactive activities, recurring sequences of behavioural events might be identified and how and to what extent each component of the pair is involved. To this aim, the multivariate temporal-pattern (t-pattern) analysis was applied to the social interactions of 9 pairs of male Wistar rats tested in open field. Interactive activities were classified into intra- and inter-subjects. Quantitative evaluations showed that intra-subject behavioural elements represented 62.37% and inter-subject ones 37.63% of the comprehensive behaviour. T-pattern analysis revealed the presence of 221 different t-patterns organized in four different categories: containing exclusively inter-subject elements; containing both inter- and intra-subject elements; consisting of rat 1 and rat 2 intra-subject elements and, finally, consisting of intra-subject elements carried out by one of the two subjects. Results show that the activity of two interacting Wistar rats is structured on the basis of several recurring temporal sequences. Moreover, social interactions appear to be expressed also by t-patterns where the behavioural elements are carried out by animals seemingly not interacting. A support of t-pattern analysis to studies on Autism Spectrum Disorders is proposed.