Assembly and trafficking of box C/D and H/ACA snoRNPs. Issue 6 (3rd June 2017)
- Record Type:
- Journal Article
- Title:
- Assembly and trafficking of box C/D and H/ACA snoRNPs. Issue 6 (3rd June 2017)
- Main Title:
- Assembly and trafficking of box C/D and H/ACA snoRNPs
- Authors:
- Massenet, Séverine
Bertrand, Edouard
Verheggen, Céline - Abstract:
- ABSTRACT: Box C/D and box H/ACA snoRNAs are abundant non-coding RNAs that localize in the nucleolus and mostly function as guides for nucleotide modifications. While a large pool of snoRNAs modifies rRNAs, an increasing number of snoRNAs could also potentially target mRNAs. ScaRNAs belong to a family of specific RNAs that localize in Cajal bodies and that are structurally similar to snoRNAs. Most scaRNAs are involved in snRNA modification, while telomerase RNA, which contains H/ACA motifs, functions in telomeric DNA synthesis. In this review, we describe how box C/D and H/ACA snoRNAs are processed and assembled with core proteins to form functional RNP particles. Their biogenesis involve several transport factors that first direct pre-snoRNPs to Cajal bodies, where some processing steps are believed to take place, and then to nucleoli. Assembly of core proteins involves the HSP90/R2TP chaperone-cochaperone system for both box C/D and H/ACA RNAs, but also several factors specific for each family. These assembly factors chaperone unassembled core proteins, regulate the formation and disassembly of pre-snoRNP intermediates, and control the activity of immature particles. The AAA+ ATPase RUVBL1 and RUVBL2 belong to the R2TP co-chaperones and play essential roles in snoRNP biogenesis, as well as in the formation of other macro-molecular complexes. Despite intensive research, their mechanisms of action are still incompletely understood.
- Is Part Of:
- RNA biology. Volume 14:Issue 6(2017)
- Journal:
- RNA biology
- Issue:
- Volume 14:Issue 6(2017)
- Issue Display:
- Volume 14, Issue 6 (2017)
- Year:
- 2017
- Volume:
- 14
- Issue:
- 6
- Issue Sort Value:
- 2017-0014-0006-0000
- Page Start:
- 680
- Page End:
- 692
- Publication Date:
- 2017-06-03
- Subjects:
- box C/D RNP -- box H/ACA RNP -- Hsp90/R2TP -- RNP assembly -- RNP trafficking -- snoRNA -- scaRNA
RNA -- Periodicals
Molecular biology -- Periodicals
Molecular biology
RNA
Periodicals
572.8805 - Journal URLs:
- http://www.tandfonline.com/loi/krnb ↗
http://www.landesbioscience.com/journals/rnabiology/ ↗
http://www.tandfonline.com/ ↗ - DOI:
- 10.1080/15476286.2016.1243646 ↗
- Languages:
- English
- ISSNs:
- 1547-6286
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 7993.991300
British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 2800.xml