The Cajal body and the nucleolus: "In a relationship" or "It's complicated"?. Issue 6 (3rd June 2017)

• Record Type: Journal Article
• Authors: Trinkle-Mulcahy, Laura; Sleeman, Judith E.
• Is Part Of: RNA biology. Volume 14:Issue 6(2017)
• Page Start: 739
• Page End: 751
• Publication Date: 2017-06-03
• Subjects: Cajal body -- coilin -- non-coding RNAs -- nuclear structure -- nuclear bodies -- nucleolus -- phase separation -- snoRNPs -- snRNPs -- telomerase; RNA -- Periodicals; Molecular biology -- Periodicals; Molecular biology; RNA; Periodicals; 572.8805
• DOI: 10.1080/15476286.2016.1236169
• Languages: English
• ISSNs: 1547-6286

Abstract

ABSTRACT: From their initial identification as 'nucleolar accessory bodies' more than a century ago, the relationship between Cajal bodies and nucleoli has been a subject of interest and controversy. In this review, we seek to place recent developments in the understanding of the physical and functional relationships between the 2 structures in the context of historical observations. Biophysical models of nuclear body formation, the molecular nature of CB/nucleolus interactions and the increasing list of joint roles for CBs and nucleoli, predominantly in assembling ribonucleoprotein (RNP) complexes, are discussed.