SMN - A chaperone for nuclear RNP social occasions?. Issue 6 (3rd June 2017)
- Record Type:
- Journal Article
- Title:
- SMN - A chaperone for nuclear RNP social occasions?. Issue 6 (3rd June 2017)
- Main Title:
- SMN - A chaperone for nuclear RNP social occasions?
- Authors:
- Raimer, Amanda C.
Gray, Kelsey M.
Matera, A. Gregory - Abstract:
- ABSTRACT: Survival Motor Neuron (SMN) protein localizes to both the nucleus and the cytoplasm. Cytoplasmic SMN is diffusely localized in large oligomeric complexes with core member proteins, called Gemins. Biochemical and cell biological studies have demonstrated that the SMN complex is required for the cytoplasmic assembly and nuclear transport of Sm-class ribonucleoproteins (RNPs). Nuclear SMN accumulates with spliceosomal small nuclear (sn)RNPs in Cajal bodies, sub-domains involved in multiple facets of snRNP maturation. Thus, the SMN complex forms stable associations with both nuclear and cytoplasmic snRNPs, and plays a critical role in their biogenesis. In this review, we focus on potential functions of the nuclear SMN complex, with particular emphasis on its role within the Cajal body.
- Is Part Of:
- RNA biology. Volume 14:Issue 6(2017)
- Journal:
- RNA biology
- Issue:
- Volume 14:Issue 6(2017)
- Issue Display:
- Volume 14, Issue 6 (2017)
- Year:
- 2017
- Volume:
- 14
- Issue:
- 6
- Issue Sort Value:
- 2017-0014-0006-0000
- Page Start:
- 701
- Page End:
- 711
- Publication Date:
- 2017-06-03
- Subjects:
- RNA -- Periodicals
Molecular biology -- Periodicals
Molecular biology
RNA
Periodicals
572.8805 - Journal URLs:
- http://www.tandfonline.com/loi/krnb ↗
http://www.landesbioscience.com/journals/rnabiology/ ↗
http://www.tandfonline.com/ ↗ - DOI:
- 10.1080/15476286.2016.1236168 ↗
- Languages:
- English
- ISSNs:
- 1547-6286
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 7993.991300
British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 2800.xml